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Chronic kidney disease (CKD) is unique in children due to varying etiology, manifestation, and impact. Whereas it is far a lesser burden compared with adult CKD, childhood CKD has a psychosocial impact on caregivers, impair growth, quality of life, and ultimately associated with increased mortality. We summarize the manifestation, diagnosis, and evaluation of a child with CKD, whose early detection, and appropriate management will improve their outcome. Thus, we hope this will be valuable to the general medical practitioners, and pediatricians in the care of children with CKD.