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Phosphorylation modifies the molecular stability of β-amyloid deposits
oleh: Nasrollah Rezaei-Ghaleh, Mehriar Amininasab, Sathish Kumar, Jochen Walter, Markus Zweckstetter
Format: | Article |
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Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Protein aggregation plays a crucial role in several neurodegenerative diseases. Here the authors demonstrate that phosphorylation of β-amyloid aggregates—the pathological hallmark of Alzheimer's disease—can change the molecular properties of aggregates, suggesting how phosphorylation contributes to disease progression.