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Fifty age and sex matched patients admitted for surgical operation, were divided into normotensive (control) and hypertensive (study) groups. Systolic and diastolic blood pressures were recorded preoperatively, 10 min after intubation, at max-increase of BP and 24 hours postoperatively. 5 ml. venous blood samples were drawn at these time periods, and serum zinc was also estimated. Control Gp (normotensive) subject recorded fall (p < 0.001) in serum Zn 10 min after intubation (n = 18) and max. Rise of BP (n = 7), Twelve subjects in study Gp recorded a rise in serum Zn at max. Increase of BP (p < 0.01). The pattern in normotensives points towards mobilization of zinc, while in hypertensives, homeostatic, defence mechanisms appear to resist mobilization of serum Zn till maximum rise in BP occurs, indicating hormonal and other influences on serum Zn levels during anaesthesia. Key Words: Serum Zinc, Systolic BP, Diastolic BP, Anaesthesia