COBRA methods and metabolic drug targets in cancer
oleh: Iñigo Apaolaza, Edurne San José-Eneriz, Xabier Agirre, Felipe Prósper, Francisco J. Planes
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-01-01 |
Deskripsi
The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform this task. Current and future steps are presented.