The mouse metallomic landscape of aging and metabolism
oleh: Jean-David Morel, Lucie Sauzéat, Ludger J. E. Goeminne, Pooja Jha, Evan Williams, Riekelt H. Houtkooper, Ruedi Aebersold, Johan Auwerx, Vincent Balter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, age-dependent, isotopically-typified and associated with a wealth of clinical and molecular traits.