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A new interactive annotation interface supports a detailed molecular animation of the SARS-CoV-2 life cycle. With this tool, users can interactively explore the data used to create the animation and engage in scientific discourse through comments and questions. A new tool for annotating scientific animations enables users to interactively explore the data used to create the animation and engage in scientific discourse through comments and questions. Iwasa and colleagues demonstrate its power with an animation of the life cycle of SARS-CoV-2.