Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
oleh: Matthew A. Lakins, Ehsan Ghorani, Hafsa Munir, Carla P. Martins, Jacqueline D. Shields
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregulation of both cell death and immune checkpoint signals.