Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
oleh: Juba Nait Saada, Georgios Kalantzis, Derek Shyr, Fergus Cooper, Martin Robinson, Alexander Gusev, Pier Francesco Palamara
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2000 years.