Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis
oleh: Hangyeol Choi, Gangadhar Rao Mathi, Seonghyeok Hong, Sungwoo Hong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
A catalytic method for the enantioselective and C4-selective functionalization of pyridine derivatives is yet to be developed. Here the authors report an efficient method for the asymmetric β-pyridylations of enals that involve N-heterocyclic carbene (NHC) catalysis with excellent control over enantioselectivity and pyridyl C4-selectivity.