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This review article describes the survey of literature regarding the variety of synthetic methods of 1,3,4-thiadiazoline and related compounds in the last seven years (2004–2010). The aim of the review is to find out different methods for the synthesis of thiadiazolines. These heterocyclics are majorly obtained from the cyclization reactions of thiosemicarbazone under the various conditions. From the literature studies it was found that major importance was given to their pharmaceutical significance i.e., regarding their biological activity against different fungal and bacterial strains.