Absolute peripheral monocyte count at diagnosis predicts central nervous system relapse in diffuse large B-cell lymphoma

oleh: Hideaki Nitta, Yasuhito Terui, Masahiro Yokoyama, Yuko Mishima, Noriko Nishimura, Kyoko Ueda, Yoshiharu Kusano, Naoko Tsuyama, Kengo Takeuchi, Yoshinobu Kanda, Kiyohiko Hatake

Format: Article
Diterbitkan: Ferrata Storti Foundation 2015-01-01

Deskripsi

Recently, elevated peripheral blood monocyte counts at diagnosis have been shown to be an independent marker associated with poor prognosis in patients with both non-Hodgkin and Hodgkin lymphoma. In this study, we retrospectively analyzed the data from a total of 550 patients with diffuse large B-cell lymphoma and evaluated the relationship between central nervous system relapse and absolute monocyte counts at diagnosis. Twenty-six patients developed central nervous system relapse. The central nervous system relapse-free survival rate was significantly lower in patients with the absolute monocyte counts ≥0.51×109/L (87.8% versus 96.4%; P