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Objective To analyze the influence of the nursing intervention on the efficacy of the improved life quality of patients with tongue cancer.Methods Forty-nine patients who had primary resection of tongue cancer were devided into the study group (25 cases) and the control group (24 cases). The study group received speech training, oral care guidance, comprehensive nursing intervention measures after leaving hospital, the control group was only for general hospital discharge guidance after a 24 to 58 months follow-up. After 24 months, all patients were asked to finish University of Washington Quality of Life version 4 to evaluate the life quality.Results Difference of the overall quality of life between experimental group and control group was statistic significant (69.8 vs 65.6) (P=0.009). In terms of individual score, there were significant differences between the two groups (51.1 vs 43.0) (P=0.002), but there was no significant difference in emotional function, oral function and social function (P>0.05).Conclusion The positive intervention of family nursing can improve the recovery of the patient's speech ability and life quality.