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The coronavirus disease 2019 (COVID-19) pandemic, caused by the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe and has affected the health of millions of people. During the pandemic, social media was the major source of information for isolated and anxious people. Infodemics is defined as “an overburden of information – some accurate and some not – that makes it hard for people to find trustworthy source and reliable guidance when they need it.” Misinformation raised out of infodemics during COVID-19 created many serious issues regarding the prevention and treatment of COVID-19. With the help of available literature, we aimed to review the role of infodemic in relation to worsening of COVID-19 spread and vaccine utilization with possible preventable measures to control infodemic. Various social media platforms were a major source of infodemic. The active role of world agencies, narrative guidelines by the local authority, use of artificial intelligence (AI) by social media platforms and active participation of community and health care professionals can control infodemics effectively.