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Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (<b>1</b>–<b>5</b>), three new dolabellane-type diterpenes, clabellanes A–C (<b>6</b>–<b>8</b>), and fifteen known compounds (<b>9</b>–<b>23</b>) were isolated from the ethanolic extract of Taiwanese soft coral <i>Clavularia</i> spp. The structures of all undescribed components (<b>1</b>–<b>8</b>) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound <b>7</b> showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC₅₀ value of 7.26 ± 0.17 μg/mL.