<i>N</i>-Arylation of 3-Formylquinolin-2(1<i>H</i>)-ones Using Copper(II)-Catalyzed Chan–Lam Coupling

oleh: Jhesua Valencia, Oriel A. Sánchez-Velasco, Jorge Saavedra-Olavarría, Patricio Hermosilla-Ibáñez, Edwin G. Pérez, Daniel Insuasty

Format: Article
Diterbitkan: MDPI AG 2022-11-01

Deskripsi

3-formyl-2-quinolones have attracted the scientific community’s attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan–Lam coupling, we synthesized 32 new <i>N</i>-aryl-3-formyl-2-quinolone derivatives at 80 °C, in air and using inexpensive phenylboronic acids as arylating agents. 3-formyl-2-quinolones and substituted 3-formyl-2-quinolones can act as substrates, and among the products, the <i>p</i>-methyl derivative <b>9a</b> was used as a substrate to obtain different derivatives such as alcohol, amine, nitrile, and chalcone.