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In hepatocytes, autophagy and ferroptosis, as important biological processes in cells, play important roles in maintaining lipid accumulation homeostasis, oxidative stress and lipid peroxidation balance. Here we reviewed the impact of autophagy on the abnormal lipids accumulation in the process of liver lipid metabolism, and its relationship with ferroptosis, which was marked by oxidative stress and lipid peroxidation. The impact of the interaction between autophagy and ferroptosis on the course of non-alcoholic fatty liver disease (NAFLD) might provide some new ideas for the treatment of NAFLD.