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The aim of the research is to determinate possible correlations between content of tumor necrosis factor alpha (TNF-α), interleukine-6 and indexes of peroxide-induced chemiluminescence (CHL) in patients with opioid dependence (ОD) on the activity of comorbid chronic hepatitis C (CHC). We examined 124 patients with ОD (96 men and 28 women) in age from 19 to 48 years, including 87 patients with comorbid CHC (69 men and 18 women) aged from 21 to 48 years. It is found that the dynamics of intensity of spontaneous, induced chemiluminescence, area of peroxide-induced chemiluminogram indicates the maximal activation of lipid peroxidation, increase in the content of prooxidant substances, reduction of buffer antioxidant capacity of blood serum in early abstinence period in patients with opioid dependence, associated with mild hepatitis activity. At the estimation of correlation of TNF-α serum level with the indexes of peroxide-induced CHL, it was set that moderate activity of comorbid CHC in comparison with low activity of hepatitis determines more significant impact of this proinflammatory cytokines on the intensity of lipid peroxidation and shift of balance «lipid peroxidation — antioxidant protection» (LP — AOP) to the activation of LP in early (R = +0.0679; P < 0.0001; R = +0.0525; P < 0.00017, respectively) and late abstinence (R = +0.0821; P < 0.0001; R = +0.0808; P < 0.0001, respectively). At moderate activity of comorbid CHC in patients with OD, interleukin-6 has the greatest impact on the increase of content of prooxidant substancesa in the blood serum in early abstinence (R = +0.0740; P < 0.0001), increase of LP activity in late abstinence (R = +0.0480; P < 0.0005; R = +0.0724; P < 0.0001), reliable shift in LP — AOP balance to the LP activation in early (R = +0.0759; P < 0.0001) and late abstinence (R = +0.0801; P < 0.0001).