Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime
oleh: Steffie Elkjær, Amanda D. Due, Lise F. Christensen, Frederik F. Theisen, Lasse Staby, Birthe B. Kragelund, Karen Skriver
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.