New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris
oleh: Ting-Hsi Hsiao, Chun-Sung Sung, Yu-Hsuan Lan, Yi-Chen Wang, Mei-Chin Lu, Zhi-Hong Wen, Yang-Chang Wu, Ping-Jyun Sung
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2015-05-01 |
Deskripsi
Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL.