Acute Low-Dose Hyperoxia during a Single Bout of High-Intensity Interval Exercise Does Not Affect Red Blood Cell Deformability and Muscle Oxygenation in Trained Men—A Randomized Crossover Study

oleh: Nils Freitag, Tim Böttrich, Pia D. Weber, Giorgio Manferdelli, Daniel A. Bizjak, Marijke Grau, Tanja C. Sanders, Wilhelm Bloch, Moritz Schumann

Format: Article
Diterbitkan: MDPI AG 2020-01-01

Deskripsi

Recent technological developments provide easy access to use an artificial oxygen supply (hyperoxia) during exercise training. The aim of this study was to assess the efficacy of a commercially available oxygen compressor inducing low-dose hyperoxia, on limiting factors of endurance performance. Thirteen active men (age 24 &#177; 3 years) performed a high-intensity interval exercise (HIIE) session (5 &#215; 3 min at 80% of W<sub>max</sub>, separated by 2 min at 40% W<sub>max</sub>) on a cycle ergometer, both in hyperoxia (4 L∙min<sup>&#8722;1</sup>, 94% O<sub>2</sub>, HYP) or ambient conditions (21% O<sub>2</sub>, NORM) in randomized order. The primary outcome was defined as red blood cell deformability (RBC-D), while our secondary interest included changes in muscle oxygenation. RBC-D was expressed by the ratio of shear stress at half-maximal deformation (SS<sup>1</sup>/<sub>2</sub>) and maximal deformability (EI<sub>max</sub>) and muscle oxygenation of the rectus femoris muscle was assessed by near-infrared spectroscopy. No statistically significant changes occurred in SS<sup>1</sup>/<sub>2</sub> and EI<sub>max</sub> in either condition. The ratio of SS<sup>1</sup>/<sub>2</sub> to EI<sub>max</sub> statistically decreased in NORM (<i>p</i> &lt; 0.01; &#916;: &#8722;0.10; 95%CI: &#8722;0.22, 0.02) but not HYP (<i>p</i> &gt; 0.05; &#916;: &#8722;0.16; 95%CI: &#8722;0.23, &#8722;0.08). Muscle oxygenation remained unchanged. This study showed that low-dose hyperoxia during HIIE using a commercially available device with a flow rate of only 4 L&#183;min<sup>&#8722;1</sup> may not be sufficient to induce acute ergogenic effects compared to normoxic conditions.