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We present a case of status epilepticus induced by hyponatremia as an adverse reaction to an antiepileptic drug. A 60 years old female was admitted to our department for partial seizures cluster activity with secondary generalization. The patient had a history of surgery for cerebral cavernoma with symptomatic epilepsy on treatment with levetiracetam and oxcarbazepine daily. Laboratory results revealed severe hyponatremia and hypokalemia. Thiopental induced coma under EEG monitoring stopped the seizure clusters. Metabolic disorders were taking in consideration and were excluded by appropriate investigations. As there were no other causes of hyponatremia, we concluded that it was an adverse event to oxcarbazepine. After the withdrawal of oxcarbazepine, the neurological status improved, with no seizures and normalization of electrolytes values confirming the hypothesis. This report illustrates a relatively uncommon adverse effect to oxcarbazepine as confirmed in the literature.