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The analysis of functioning ofcomplex production systems in agroindustrial sphere — largecrop farms and livestock farms — shows that the basis for dynamic development of their productive activities is based on a reliable and stable operation of the complex biotech (human-machine) systems. Urgent problems, whose solution promotes a dynamic and efficient operation of complex biotechnological systems, are to create mathematical models of the total biotech system, allowing sufficiently informatively guide the work of major agricultural organizations. This paper discusses an alternative methodological approach to assessing and forecasting financial sustainability of an enterprise. An important place among the factors that shape the financial stability of the economic entity, takes the human factor (decision maker). Financial sustainability of the enterprise is seen from the perspective of bio-approach that includes elements of the system MME (man, machine, and environment). This approach improves the results when evaluating the adequacy of the financial stability of companies in various states of the economy. Newly developed approaches and mathematical models to managesystems of biotechnology makeit possibleto significantly increase the productivity of animals, crop production and the level of socio-economic status of people in the country.