Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism
oleh: Xiaodi Tang, Shenghai Chang, Qinghua Luo, Zhengyu Zhang, Wen Qiao, Caihuang Xu, Changbin Zhang, Yang Niu, Wenxian Yang, Ting Wang, Zhibo Zhang, Xiaofeng Zhu, Xiawei Wei, Changjiang Dong, Xing Zhang, Haohao Dong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Seven lipopolysaccharide (LPS) transport proteins (LptBFGCADE) mediate the transport of LPS from the inner to the outer membrane of Gram-negative bacteria. Here the authors provide mechanistic insights into LPS recognition and transportation by determining the cryo-EM structures of the inner membrane complex LptB2FGC bound to either LPS or AMP-PNP.