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Background: Hepatic cyst hydatid infection is caused by microorganisms named echinococcus which belong to family Taenidae. Platelets are considered as a mediator in inflammation and infectious diseases because of the various  proinflammatory substances that they contain. Design and Methods: Thirty three patients who admitted to Do?ubayaz?t State Hospital’s general surgery clinic with a diagnosis of hepatic cyst hydatid were enrolled to this retrospective study. Laboratory data of the patients in pre- and post-operative periods were obtained by computerized medical records database of the hospital Results: Pre-operative Mean platelet volume (MPV) of the patients was significantly increased compared to postoperative MPV values. Conclusion: We claim that MPV is a useful follow up marker after surgery in patients with hydatid cyst.