Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives
oleh: Lyudmila G. Lavrenova, Taisiya S. Sukhikh, Lyudmila A. Glinskaya, Svetlana V. Trubina, Valentina V. Zvereva, Alexander N. Lavrov, Lyubov S. Klyushova, Alexander V. Artem’ev
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-08-01 |
Deskripsi
New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L<sup>1</sup>) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L<sup>2</sup>) with compositions Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub>, Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, Cu(L<sup>2</sup>)Cl<sub>2</sub>, and Cu(L<sup>2</sup>)Br<sub>2</sub> were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L<sup>1</sup> were determined. The structures of the coordination core of complexes Cu(L<sup>2</sup>)Cl<sub>2</sub> and Cu(L<sup>2</sup>)Br<sub>2</sub> were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub> to alternating-exchange antiferromagnetic chains in Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, where double dicyanamide bridges provide an unusually strong exchange interaction (J<sub>1</sub>/k<sub>B</sub> ≈ −23.5 K; J<sub>2</sub>/k<sub>B</sub> ≈ −20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L<sup>2</sup> was estimated on the human cell lines of breast adenocarcinoma (<i>MCF-7</i>) and hepatocellular carcinoma (<i>HepG2</i>).