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ProteoClade: A taxonomic toolkit for multi-species and metaproteomic analysis.
oleh: Arshag D Mooradian, Sjoerd van der Post, Kristen M Naegle, Jason M Held
Format: | Article |
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Diterbitkan: | Public Library of Science (PLoS) 2020-03-01 |
Deskripsi
We present ProteoClade, a Python toolkit that performs taxa-specific peptide assignment, protein inference, and quantitation for multi-species proteomics experiments. ProteoClade scales to hundreds of millions of protein sequences, requires minimal computational resources, and is open source, multi-platform, and accessible to non-programmers. We demonstrate its utility for processing quantitative proteomic data derived from patient-derived xenografts and its speed and scalability enable a novel de novo proteomic workflow for complex microbiota samples.