ProteoClade: A taxonomic toolkit for multi-species and metaproteomic analysis.

oleh: Arshag D Mooradian, Sjoerd van der Post, Kristen M Naegle, Jason M Held

Format: Article
Diterbitkan: Public Library of Science (PLoS) 2020-03-01

Deskripsi

We present ProteoClade, a Python toolkit that performs taxa-specific peptide assignment, protein inference, and quantitation for multi-species proteomics experiments. ProteoClade scales to hundreds of millions of protein sequences, requires minimal computational resources, and is open source, multi-platform, and accessible to non-programmers. We demonstrate its utility for processing quantitative proteomic data derived from patient-derived xenografts and its speed and scalability enable a novel de novo proteomic workflow for complex microbiota samples.