Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
oleh: Michael J. Petrany, Casey O. Swoboda, Chengyi Sun, Kashish Chetal, Xiaoting Chen, Matthew T. Weirauch, Nathan Salomonis, Douglas P. Millay
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-12-01 |
Deskripsi
Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.