Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
oleh: Bart Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David Traver, Alex Groisman, Eugene Tkachenko
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.