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Aims: The correct transition in postoperative care, from the post-anesthesia care unit (PACU) to the general ward or even home discharge, is an essential step in the discharge of surgical patients. The present study was conducted with the aim of psychometrics and localization of the Persian version of the patient evaluation and discharge checklist in the post-anesthesia care unit. Materials and Methods: This cross-sectional study was conducted in the paramedical faculty of Iran University of Medical Sciences in 2022. In this study, the psychometrics and localization of the Persian version of the patient assessment and discharge checklist in the post-anesthesia care unit (SAMPE checklist) were evaluated. The translation tool was implemented using the forward-backward method, and the clinical validation of the tool was done by determining face validity (qualitative) and content validity (content validity index). Also, to check the tool's reliability, the inter-rater reliability method was performed using the Kappa coefficient. SPSS version 26 software was used for statistical analysis. Findings: The present research was conducted on 80 patients of the PACU with a mean age of 45 years (minimum = 18 years, maximum = 89 years). Patients were selected non-randomly (convenience samples) from the PACU and participated in the study after informing their consent. Demographic and anesthesia-surgery characteristics are provided in Table 1. Content validity was reported as 0.94 using CVI (Table 2). For eight items of the checklist, a CVI over 0.79 was reported, indicating the favorable content validity of all items (Table 2). The face validity of the SAMPE checklist was assessed qualitatively using the recovery nurses’ comments. The recovery nurses approved all the items regarding the items’ level of difficulty, appropriateness, and ambiguity; thus, no change was made to the items. In order to assess the reliability, the kappa coefficient was calculated, the value of which was 0.31-1, indicating the appropriateness of the tool’s reliability (Table 3). Conclusion: The research findings show the tool's face validity, content validity, and appropriate reliability. Based on this, the psychometric and localized patient evaluation and discharge checklist in the post-anesthesia care unit (SAMPE checklist) in this research can be used to determine the readiness of patients for discharge from the PACU. CLINICAL & PRACTICAL TIPS in POLICE MEDICINE: The Persian version of the SAMPE checklist is a simple and practical tool for safely discharging patients from the post-anesthesia care unit. A medical staff of military and police forces can use this checklist as a quick and safe method to evaluate and discharge patients in the post-anesthesia care unit. ACKNOWLEDGMENTS: The treatment staff of the operating room and PACU of Rasoul Akram Hospital in Tehran, Iran, were appreciated. CONFLICT of INTEREST: The authors stated that there is no conflict of interest. AUTHORS CONTRIBUTION: Mohammad Gholamzadeh in data collection; Azam Saei in the presentation of the idea and design of the study; Shahnam Sedigh Maroufi in presenting the idea and design of the study; Tahereh Sadat Khoobbin Khoshnazar in data interpretation; Rezvaneh Rajabzadeh in statistical data analysis; All the authors participated in the initial writing of the article and its revision, and all of them accept the responsibility for the accuracy and correctness of the contents of this article with the final approval of this article. FUNDING SOURCES: The research vice-chancellor of the Paramedical Faculty of Iran, University of Medical Sciences, was the financial support of this research.