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Neurovitan may be the drug of choice in the implementation of complex therapy of neurotropic vitamins in patients with endocrine pathology. Objectiv: to study the effectiveness of Neurovitan  in the complex treatment of endocrine polyendocrinopathy. Materials and methods: we examined 18 patients with diabetes mellitus and 15 patients with hypothyroidism. All patients were diagnosed distal polyneuropathy of the hands and feet. The drug Neurovitan took all patients 1 table. 4 times a day for 2 months. Conclusions: the use of the drug Neurovitan in the treatment of patients with diabetes and hypothyroidism can prevent violations that are a consequence of polyneuropathy.