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This study presents a comprehensive analysis of the length-weight relationship, condition factors, and age of <i>Schizothorax eurystomus</i> in the Shakhimardan River basin in Central Asia, along with a comparative perspective to other <i>Schizothorax</i> species in the region. The study found that <i>S. eurystomus</i> exhibits positive allometric growth, which is consistent with similar patterns observed in this species from the Syr Darya River basin. The two analyzed condition factors showed mean values within the normal range, indicating good feeding and environmental conditions. However, significant disparities between minimum and maximum values of these factors indicated varied growth conditions which may be influenced by anthropogenic factors. Age estimation using opercular bones showed variations in the total length among fish of the same age, and a clear age distribution pattern across different sites. Younger fish predominantly inhabited the shallower, warmer, and lower sections of the river, which is impacted by agricultural water diversion, while older specimens were found in areas with higher discharge and deeper pools. Overall, this research provides valuable insights into the life history traits of <i>S. eurystomus</i>, underlining the need for sustainable fishery management and conservation strategies in the Shakhimardan River basin. The findings also emphasize the importance of considering habitat quality and anthropogenic pressures regarding understanding both fish population dynamics and growth patterns.