Stereoselective one-pot synthesis of polypropionates

oleh: Guo-Ming Ho, Medel Manuel L. Zulueta, Shang-Cheng Hung

Format: Article
Diterbitkan: Nature Portfolio 2017-09-01

Deskripsi

Polypropionates are present in many natural products possessing high bioactivity and therapeutic value. Here the authors show a strategy for the stereoselective assembly of polypropionates with three or four stereocentres through a process that includes a Diels–Alder reaction, silylenol ether hydrolysis and Baeyer–Villiger oxidation.