Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
oleh: Ruby C.Y. Lin, Sheau-Fang Ng, Margaret J. Morris
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2014-12-01 |
Deskripsi
Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963–966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830–1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.