An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers
od: Jing An, Shanliang Tang, Gaobo Hong, Wenlong Chen, Miaomiao Chen, Jitao Song, Zhiliang Li, Xiaojun Peng, Fengling Song, Wen-Heng Zheng
| Format: | Article |
|---|---|
| Izdano: | Nature Portfolio 2022-04-01 |
Opis
Type I photodynamic therapy (PDT) sensitizers show good hypoxia tolerance but only few strategies are available for the design of purely organic Type I photosensitizers (PS). Here, the authors use biotinylation as design strategy to obtain PS-Biotin sensitizers with high efficiency for the generation of superoxide anion radicals and singlet oxygen.