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The goal of this study is to describe the class of modified Sehgal–Guseman-like contraction mappings and set up some fixed-point results in <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">S</mi></semantics></math></inline-formula>-metric spaces. The class of generalized Sehgal–Guseman-like contraction mappings contains enhancements of Banach contractions, Kannan contractions, Chatterjee contractions, Chatterjee-type contractions, quasi-contractions, Ćirić–Reich–Rus-type contractions, Hardy–Rogers-type contractions, Reich-type contractions, interpolative Kannan contractions, interpolative Chatterjee contractions, among others, with their generalizations in <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">S</mi></semantics></math></inline-formula>-metric spaces. We offer significant examples to substantiate the reliability of our results. This study also establishes consequential fixed-point results and applies them to nonlinear fractional differential equations and the boundary value problem for homogeneous transverse bars. At the end of the manuscript, we present an important open problem.