Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
oleh: Diana M. Mitrea, Jaclyn A. Cika, Christopher B. Stanley, Amanda Nourse, Paulo L. Onuchic, Priya R. Banerjee, Aaron H. Phillips, Cheon-Gil Park, Ashok A. Deniz, Richard W. Kriwacki
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-02-01 |
Deskripsi
The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome biogenesis process.