SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila
oleh: Vittoria Mariano, Alexandros K. Kanellopoulos, Giuseppe Aiello, Adrian C. Lo, Eric Legius, Tilmann Achsel, Claudia Bagni
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
Mechanisms underlying sleep dysfunctions in neurodevelopmental disorders remain elusive. Here, authors use a fly model for the CYFIP haploinsufficiency to show that increased SREBP activity impairs the NADP+/NADPH homeostasis inducing sleep deficits.