Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
oleh: Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.