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Context: Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group. Aims: The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group. Settings and Design: Retrospective analysis was carried out at a single center in India. Materials and Methods: Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis. Statistical Analysis Used: The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS. Results: CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign. Conclusions: The treatment with Imatinib was effective and well-tolerated.