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Secondary malignancies following treatment of primary carcinomas have been reported in the literature and serious debate has emerged regarding the risk of secondary malignancies post therapy along with risk associated with different regimens. (chemotherapy / radiotherapy). The present report describes two cases of multiple myeloma following carcinoma cervix and intraductal carcinoma breast post therapy after three and fifteen years respectively and thus highlights the risk of multiple myeloma associated with different regimens of treatment of solid carcinomas. It also lays the importance of balance between the benefits of therapy of carcinoma and the risk of treatment associated multiple myeloma. The cases specify the need of vigilant follow up of any primary carcinoma, irrespective of time, in the light of early detection of secondary malignancy.