A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress
oleh: Wezley C. Griffin, David R. McKinzey, Kathleen N. Klinzing, Rithvik Baratam, Achini Eliyapura, Michael A. Trakselis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
The MCM8/9 helicase has been implicated in DNA recombination processes with mutations in these genes causative for infertility and cancer. Here, the authors show that MCM8/9 aids normal fork progression and also stabilizes persistently stalled forks, acting upstream of RAD51 and BRCA1.