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In this article, the effects of a Casson Nanofluid boundary layer flow, over an inclined extending surface with Soret and Dufour, is scrutinized. The model used in this study is based on the Buongiorno model of the thermal efficiencies of the fluid flows in the presence of Brownian motion and thermophoresis properties. The non-linear problem for Casson Nanofluid flow over an inclined channel is modeled to gain knowledge on the heat and mass exchange phenomenon, by considering important flow parameters of the intensified boundary layer. The governing non-linear partial differential equations are changed to non-linear ordinary differential equations and are afterward illustrated numerically by the Keller-Box scheme. A comparison of the established results, if the incorporated effects are lacking, is performed with the available outcomes of Khan and Pop [1] and recognized in a nice settlement. Numerical and graphical results are also presented in tables and graphs.