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The main purpose of this study is to investigate the multislip effects on the magneto-hydrodynamic (MHD) mixed convection unsteady flow of micropolar nano-fluids over a stretching/shrinking sheet along with radiation in the presence of a heat source. The consequences of multislip and buoyancy conditions have been integrated. By using the suitable similarity variables are used to solve the governing non-linear partial differential equations into a system of coupled non-linear ordinary differential equations. The transformed equations are solved numerically by using Runge−Kutta fourth-order method with shooting technique. The impacts of the several parameters on the velocity, temperature, micro-rotation, and concentration profiles as well as on the skin friction coefficient, Sherwood number, and Nusselt number are discussed with the help of graphs and tables.