Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
oleh: Yin-Di Su, Tzu-Rong Su, Zhi-Hong Wen, Tsong-Long Hwang, Lee-Shing Fang, Jih-Jung Chen, Yang-Chang Wu, Jyh-Horng Sheu, Ping-Jyun Sung
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2015-02-01 |
Deskripsi
Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.