Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
oleh: Homa Rahnamoun, Hanbin Lu, Sascha H. Duttke, Christopher Benner, Christopher K. Glass, Shannon M. Lauberth
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.