Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
oleh: Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-10-01 |
Deskripsi
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease