Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
oleh: Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, Leif W. Ellisen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-09-01 |
Deskripsi
Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcomes.