LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
oleh: Zhen-zhen Chen, Lan Huang, Ya-hong Wu, Wen-jie Zhai, Ping-ping Zhu, Yan-feng Gao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
Liver tumour-initiating cells (TICs) may be responsible for liver cancer initiation and recurrence. In this article, the authors show that a previously unidentified lncRNA, LncSox4, is highly expressed in liver cancer TICs and regulates TIC self-renewal through the Stat3/SOX4 axis.