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The paper presents experimental and numerical investigations performed on a single stage, single-suction, horizontal-orientated centrifugal pump in air–water two-phase non-condensable flow conditions. Experimental measurements are performed in a centrifugal pump using pressure sensor devices in order to measure the wall static pressures at the inlet and outlet pump sections for different flow rates and rotational speeds combined with several air void fraction (<i>a</i>) values. Two different approaches are used in order to predict the pump performance degradations and perform comparisons with experiments for two-phase flow conditions: a one-dimensional two-phase bubbly flow model, and a full “Three-Dimensional Unsteady Reynolds Average Navier–Stokes” (3D-URANS) simulation using a modified <i>k-epsilon</i> turbulence model combined with the Euler–Euler inhomogeneous two-phase flow description. The overall and local flow features are presented and analyzed. Limitations concerning both approaches are pointed out according to some flow physical assumptions and measurement accuracies. Some additional suggestions are proposed in order to improve two-phase flow pump suction capabilities.