Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination
oleh: He-Yuan Bai, Fu-Xin Tan, Tuan-Qing Liu, Guo-Dong Zhu, Jin-Miao Tian, Tong-Mei Ding, Zhi-Min Chen, Shu-Yu Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Atropisomers with a chiral C-N axis are useful for natural products synthesis and as ligands in asymmetric catalysis. Here, the authors reportt a π-π interaction and dual H-bond concerted control strategy in enantioselective C-H amination affording configurationally stable N-C atropisomers.